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J Cutan Pathol 31(1):3542 Basavaraj KH, Ashok NM, Rashmi R, Praveen TK (2010) The role of drugs in the induction and/or exacerbation of psoriasis

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S-acetylglutathione has also been shown to decrease TNF-alpha, NF-kappa beta, and F-2 isoprostane.[4,9-12] Additionally, there is mounting evidence that intracellular glutathione levels in antigen-presenting cells (e.g macrophages) may influence the Th1/Th2 cytokine response pattern and promote a balanced immune reaction.*[10]

ATF4 Activating transcription factor 4 (ATF4) is another key transcriptional regulator and mediator of metabolism and oxidative homeostasis (76, 119) that can be activated by several stress signals, such as those triggered by anoxia, hypoxia, endoplasmic reticulum (ER) stress, oxidative stress and amino acid deprivation (120)